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Preparation of Poly(3-hydroxybutyrate) based acrylic monomer
Liška, Marek ; Přikryl, Radek (referee) ; Figalla, Silvestr (advisor)
The main aim of this thesis is to research and prepare acrylic (methacrylic) monomers derived from poly(3-hydroxybutyrate). The monomers were prepared in two-step syntheses. In the first step P3HB was depolymerised with selected alcohols and afterwards, products of those syntheses were used as substrate and mixed with polymethylmethacrylate to produce their methacrylic derivates. The selected alcohols for the alcoholysis were ethanol and ethylene glycol. In total, four substances were prepared. Products of alcoholysis were ethyl-3- hydroxybutyrate, 2-hydroxyethyl-3-hydroxybutyrate and their methacrylic derivates. Significant part of this thesis is aimed towards the analysis of prepared substances and the analysis of reactions. In the process, titrations and instrumental methods, such as gel permeation chromatography (GPC), infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), thermogravimetry (TGA) and differential scanning calorimetry (DSC) were used. This work describes preparation and analysis of polymers prepared from methacrylates from the mentioned syntheses. Cross-linked polymers, because of their low glass-transition temperature are elastomers.
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Preparation of 3-phenylpentanoic and 3-phenylpent-2-enoic acid derivatives
Fatka, David ; Machara, Aleš (advisor) ; Veselý, Jan (referee)
This Bachelor's thesis deals with preparation of the intermediates of the analgesic tapentadol. The chosen synthetic strategy requires a preparation of appropriate derivatives of 3-phenylpentanoic and 3-phenylpent-2-enoic acid. Synthesis of those derivatives represents the cornerstone of the thesis. In the first part, the thesis describes an effort associated with a preparation of 1-[(3-benzyloxy)phenyl]propan-1-one, a necessary intermediate for the preparation of the titled compounds. Then addition reactions were studied on the aforementioned ketone. The second part of the thesis focuses on one particular addition, a Reformatsky reaction, and deals with further optimization. In addition, the submitted thesis also describes variety of attempts to carry out dehydration of the Reformatsky adducts, namely, benzylic tertiary alcohols. Powered by TCPDF (www.tcpdf.org)
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Preparation of Poly(3-hydroxybutyrate) based acrylic monomer
Liška, Marek ; Přikryl, Radek (referee) ; Figalla, Silvestr (advisor)
The main aim of this thesis is to research and prepare acrylic (methacrylic) monomers derived from poly(3-hydroxybutyrate). The monomers were prepared in two-step syntheses. In the first step P3HB was depolymerised with selected alcohols and afterwards, products of those syntheses were used as substrate and mixed with polymethylmethacrylate to produce their methacrylic derivates. The selected alcohols for the alcoholysis were ethanol and ethylene glycol. In total, four substances were prepared. Products of alcoholysis were ethyl-3- hydroxybutyrate, 2-hydroxyethyl-3-hydroxybutyrate and their methacrylic derivates. Significant part of this thesis is aimed towards the analysis of prepared substances and the analysis of reactions. In the process, titrations and instrumental methods, such as gel permeation chromatography (GPC), infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), thermogravimetry (TGA) and differential scanning calorimetry (DSC) were used. This work describes preparation and analysis of polymers prepared from methacrylates from the mentioned syntheses. Cross-linked polymers, because of their low glass-transition temperature are elastomers.
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Preparation of 3-phenylpentanoic and 3-phenylpent-2-enoic acid derivatives
Fatka, David ; Machara, Aleš (advisor) ; Veselý, Jan (referee)
This Bachelor's thesis deals with preparation of the intermediates of the analgesic tapentadol. The chosen synthetic strategy requires a preparation of appropriate derivatives of 3-phenylpentanoic and 3-phenylpent-2-enoic acid. Synthesis of those derivatives represents the cornerstone of the thesis. In the first part, the thesis describes an effort associated with a preparation of 1-[(3-benzyloxy)phenyl]propan-1-one, a necessary intermediate for the preparation of the titled compounds. Then addition reactions were studied on the aforementioned ketone. The second part of the thesis focuses on one particular addition, a Reformatsky reaction, and deals with further optimization. In addition, the submitted thesis also describes variety of attempts to carry out dehydration of the Reformatsky adducts, namely, benzylic tertiary alcohols. Powered by TCPDF (www.tcpdf.org)
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